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quinupristin/dalfopristin will boost the amount or result of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.quinupristin/dalfopristin will enhance the degree or influence of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.quinupristin/dalfopristin will increase